The developed detection platform is based on an integrated optical biosensor using Si3N4/SiO2 waveguide technology. Different sensor designs can be made based on this technology, including microring resonators (MRR) and Mach-Zehnder interferometers (MZI). Recently, it was found that introducing an asymmetry between the two arms of an MZI improves the sensitivity of the device. In BioMeander, the design of the asymmetric MZI will be optimized for maximum sensor performance.
To further enhance the sensitivity and limit of detection, Surfix’s nanocoatings will be used for material selective (bio)functionalization of the aMZI biosensor. Application-specific nanocoatings are developed to optimize the coating properties to obtain the best results for the two application examples, discovery of small molecule therapeutics and detection of influenza virus.