Material-selective nanocoatings

Surfix’s material-selective nanocoatings have been specifically developed to optimize the performance of biochips. The surfaces of Surfix’s photonic biochips consist of more than one material and benefit from material-selective surface modification. The sensing element can be functionalized with a nanocoating for immobilization of bioreceptors, whereas anti-biofouling moieties can be incorporated on the surrounding surface to prevent non-specific protein adsorption. By combining both functionalities on the surface, material-selective nanocoatings enhance sensitivity and selectivity and therefore improve biosensor performance.

INcreasing sensitivity

The photonic biochip, which is based on TripleX waveguide technology developed by our partner Lionix, International consists of silicon nitride and silicon oxide as waveguide and cladding materials, respectively. Binding of analyte molecules to the waveguide causes a change in the light output of the sensor. The cladding, on the other hand, does not contribute to the sensor signal. Read more about the structure of our photonic biochip.

As the waveguide makes up less than 1% of the sensor surface, using a uniform nanocoating for biofunctionalization (left image) results in the bioreceptor being immobilized on the whole sensor surface. That means 99% of the bound analyte remains undetected.

Therefore, a significant improvement can be realized when a material-selective nanocoating is used to immobilize the bioreceptor only on the waveguide, and an antifouling nanocoating is applied on the rest of the surface (right image).  Important benefits of the material-selective nanocoating are:

  • increased sensitivity
  • lower limit of detection
  • reduced non-specific adsorption

We believe that our material-selective coating enhances the performance of lab-on-a-chip devices. 
Contact us here for more information and to discuss your requirements.