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Nanocoatings for biosensors
The immobilization of a bioreceptor is a key step in the manufacture of any biosensor, as this enables the sensitive and selective detection of the analyte of interest. Depending on the type of sensor and analyte, the right surface modification strategy has to be chosen to ensure the optimal nanocoating thickness and density of bioreceptors.
Surfix’s Hydroix technology is ideally suited for biosensor functionalization, since both 2D and 3D nanocoatings can be prepared to which antibodies, aptamers or other bioreceptors can be directly coupled.
PATTERNING
Often, detection does not take place on the whole sensor surface but in a smaller detection area. In this case, the nanocoating can be patterned by material- selective or local surface modification, so that the bioreceptors are only immobilized in the detection area. By doing so, the analyte is concentrated and the sensitivity of the sensor is increased.
Benefits
- biofunctionalization of various sensor materials
- different functional groups for bioimmobilization
- tuneable thickness and density of bioreceptors
- reduced non-specific adsorption
- improved sensitivity and limit of detection